Many studies analysed and described the effects of music listening in the management of pain in adult patients. Most of them found a significant effect of music on pain. A new study shows that music reduces pain perception in healthy new-borns undergoing painful medical procedures. In the study of 80 full-term new-borns, aged 1 to 3 days, randomly allocated to exposure to Mozart’s Sonata for two pianos K. 448, Beethoven’s Moonlight Sonata, heartbeat sound recordings (70 bpm) or no music showed that infants who were exposed to the three music interventions displayed a significant reduction in heart rate and in pain perception and an increase in oxygen saturation, as compared to the control group, which showed less modifications on stress measurements after painful medical procedures.